Is it possible to connect ACCDB file on OneDrive from PowerApps?

Can PowerApps connect to Microsoft Access?

It is not possible to port MS Access forms over to PowerApps, but there are workarounds. You can create an app that connects to MS Access tables. You can then run your usual queries, reports etc within MS Access. The best way to do this is to use a SharePoint list.

Can you put Access database on OneDrive?

Warning Although you can save an Access database file to OneDrive or a SharePoint document library, we recommend that you avoid opening an Access database from these locations. The file may be downloaded locally for editing and then uploaded again once you save your changes to SharePoint.